Version 5.4
Mus musculus Protein: Gpbar1
Summary
InnateDB Protein IDBP-166513.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Gpbar1
Protein Name G protein-coupled bile acid receptor 1
Synonyms
Species Mus musculus
Ensembl Protein ENSMUSP00000077135
InnateDB Gene IDBG-166511 (Gpbar1)
Protein Structure
UniProt Annotation
Function Receptor for bile acid. Bile acid-binding induces its internalization, activation of extracellular signal-regulated kinase and intracellular cAMP production. May be involved in the suppression of macrophage functions by bile acids (By similarity). Involved in bile acid promoted GLP1R secretion. {ECO:0000250, ECO:0000269PubMed:15721318}.
Subcellular Localization Cell membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0004930 G-protein coupled receptor activity
GO:0038181 bile acid receptor activity
Biological Process
GO:0007186 G-protein coupled receptor signaling pathway
GO:0038183 bile acid signaling pathway
Cellular Component
GO:0005737 cytoplasm
GO:0005886 plasma membrane
GO:0016021 integral component of membrane
Protein Structure and Domains
PDB ID MGI:2653863
InterPro IPR000276 G protein-coupled receptor, rhodopsin-like
IPR017452 GPCR, rhodopsin-like, 7TM
PFAM PF00001
PRINTS PR00237
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q80SS6
PhosphoSite PhosphoSite-
TrEMBL Q14AA9
UniProt Splice Variant
Entrez Gene 227289
UniGene Mm.246587
RefSeq NP_778150
MGI ID
MGI Symbol Gpbar1
OMIM
CCDS CCDS15042
HPRD
IMGT
EMBL AB086171 AB089308 BC116914 BC119327 CH466548
GenPept AAI16915 AAI19328 BAC55236 BAC65344 EDL00311

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca