InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Klb

Summary

InnateDB Protein

IDBP-166516.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Klb

Protein Name

klotho beta

Synonyms

AV071179; betaKlotho;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000031096

InnateDB Gene

IDBG-166514 (Klb)

Protein Structure

UniProt Annotation

Function

Contributes to the transcriptional repression of cholesterol 7-alpha-hydroxylase (CYP7A1), the rate-limiting enzyme in bile acid synthesis. Probably inactive as a glycosidase. Increases the ability of FGFR1 and FGFR4 to bind FGF21. {ECO:0000269PubMed:16075061, ECO:0000269PubMed:17452648}.

Subcellular Localization

Cell membrane {ECO:0000305}; Single-pass type III membrane protein {ECO:0000305}.

Disease Associations

Tissue Specificity

Present in liver, muscle and white adipose tissue, but not in kidney (at protein level). Expressed in liver and pancreas, and at lower levels in skin, stomach, skeletal muscle, small intestine and lung. {ECO:0000269PubMed:11044614, ECO:0000269PubMed:16075061, ECO:0000269PubMed:17452648}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	4 [view]
Protein-Protein	4 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004553	hydrolase activity, hydrolyzing O-glycosyl compounds
GO:0005515	protein binding
GO:0017134	fibroblast growth factor binding

Biological Process

GO:0005975	carbohydrate metabolic process
GO:0008284	positive regulation of cell proliferation
GO:0008543	fibroblast growth factor receptor signaling pathway
GO:0090080	positive regulation of MAPKKK cascade by fibroblast growth factor receptor signaling pathway