Mus musculus Protein: Dennd4b
Summary
InnateDB Protein IDBP-166534.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Dennd4b
Protein Name DENN/MADD domain containing 4B
Synonyms
Species Mus musculus
Ensembl Protein ENSMUSP00000096514
InnateDB Gene IDBG-166532 (Dennd4b)
Protein Structure
UniProt Annotation
Function Guanine nucleotide exchange factor (GEF) which may activate RAB10. Promotes the exchange of GDP to GTP, converting inactive GDP-bound Rab proteins into their active GTP-bound form (By similarity). {ECO:0000250}.
Subcellular Localization Golgi apparatus.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
Experimentally validated
Total 1 [view]
Protein-Protein 0
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0017112 Rab guanyl-nucleotide exchange factor activity
Biological Process
GO:0032313 regulation of Rab GTPase activity
GO:0032483 regulation of Rab protein signal transduction
GO:0032851 positive regulation of Rab GTPase activity
Cellular Component
GO:0005634 nucleus
GO:0005794 Golgi apparatus
Protein Structure and Domains
PDB ID MGI:2446201
InterPro IPR001194 DENN domain
IPR002885 Pentatricopeptide repeat
IPR005112 dDENN domain
IPR005113 uDENN domain
PFAM PF02141
PF01535
PF12854
PF13041
PF13812
PF03455
PF03456
PRINTS
PIRSF
SMART SM00799
SM00801
SM00800
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q3U1Y4
PhosphoSite PhosphoSite-Q3U1Y4
TrEMBL B9EKY0
UniProt Splice Variant
Entrez Gene 229541
UniGene Mm.409298
RefSeq NP_958809
MGI ID
MGI Symbol Dennd4b
OMIM
CCDS CCDS38502
HPRD
IMGT
EMBL AK122294 AK155638 AY512564 BC026996 BC040460 BC049972 BC066102 BC151194
GenPept AAH26996 AAH40460 AAH49972 AAH66102 AAI51195 AAR97575 BAC65576 BAE33359