InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Trip13

Summary

InnateDB Protein

IDBP-166580.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Trip13

Protein Name

thyroid hormone receptor interactor 13

Synonyms

2410002G23Rik; D13Ertd328e;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000022053

InnateDB Gene

IDBG-166578 (Trip13)

Protein Structure

UniProt Annotation

Function

Plays a key role in chromosome recombination and chromosome structure development during meiosis. Required at early steps in meiotic recombination that leads to non-crossovers pathways. Also needed for efficient completion of homologous synapsis by influencing crossover distribution along the chromosomes affecting both crossovers and non-crossovers pathways. Also required for development of higher-order chromosome structures and is needed for synaptonemal-complex formation. In males, required for efficient synapsis of the sex chromosomes and for sex body formation. Promotes early steps of the DNA double- strand breaks (DSBs) repair process upstream of the assembly of RAD51 complexes. Required for depletion of HORMAD1 and HORMAD2 from synapsed chromosomes. {ECO:0000269PubMed:17696610, ECO:0000269PubMed:19851446, ECO:0000269PubMed:20711356}.

Subcellular Localization

Disease Associations

Tissue Specificity

Widely expressed, including in testis. {ECO:0000269PubMed:20711356}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.
They are also associated with 63 interaction(s) predicted by orthology.

Experimentally validated
Total	8 [view]
Protein-Protein	8 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	63 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000166	nucleotide binding
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0017111	nucleoside-triphosphatase activity
GO:0042802	identical protein binding

Biological Process

GO:0001556	oocyte maturation
GO:0006302	double-strand break repair
GO:0007130	synaptonemal complex assembly
GO:0007131	reciprocal meiotic recombination
GO:0007141	male meiosis I
GO:0007144	female meiosis I
GO:0007283	spermatogenesis
GO:0007286	spermatid development
GO:0048477	oogenesis