InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Exosc1

Summary

InnateDB Protein

IDBP-166583.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Exosc1

Protein Name

exosome component 1

Synonyms

2610035C18Rik; 2610104C07Rik; 2610312F07Rik; AI447561;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000074756

InnateDB Gene

IDBG-166581 (Exosc1)

Protein Structure

UniProt Annotation

Function

Non-catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the nucleus, the RNA exosome complex is involved in proper maturation of stable RNA species such as rRNA, snRNA and snoRNA, in the elimination of RNA processing by-products and non-coding 'pervasive' transcripts, such as antisense RNA species and promoter-upstream transcripts (PROMPTs), and of mRNAs with processing defects, thereby limiting or excluding their export to the cytoplasm. The RNA exosome may be involved in Ig class switch recombination (CSR) and/or Ig variable region somatic hypermutation (SHM) by targeting AICDA deamination activity to transcribed dsDNA substrates. In the cytoplasm, the RNA exosome complex is involved in general mRNA turnover and specifically degrades inherently unstable mRNAs containing AU-rich elements (AREs) within their 3' untranslated regions, and in RNA surveillance pathways, preventing translation of aberrant mRNAs. It seems to be involved in degradation of histone mRNA. The catalytic inactive RNA exosome core complex of 9 subunits (Exo-9) is proposed to play a pivotal role in the binding and presentation of RNA for ribonucleolysis, and to serve as a scaffold for the association with catalytic subunits and accessory proteins or complexes. EXOSC1 as peripheral part of the Exo-9 complex stabilizes the hexameric ring of RNase PH-domain subunits through contacts with EXOSC6 and EXOSC8 (By similarity). {ECO:0000250}.

Subcellular Localization

Nucleus, nucleolus. Nucleus {ECO:0000250}. Cytoplasm {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 24 interaction(s) predicted by orthology.

Experimentally validated
Total	2 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	24 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003723	RNA binding
GO:0005515	protein binding

Biological Process

GO:0006364

rRNA processing

Cellular Component

GO:0000178	exosome (RNase complex)
GO:0005634	nucleus
GO:0005730	nucleolus
GO:0005737	cytoplasm

Protein Structure and Domains

PDB ID

MGI:1913833

InterPro

IPR012340 Nucleic acid-binding, OB-fold
IPR019495 Exosome complex component CSL4
IPR022967 RNA-binding domain, S1

PFAM

PF10447

PRINTS

PIRSF

SMART

SM00316

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q9DAA6

PhosphoSite

PhosphoSite-Q9DAA6

TrEMBL

UniProt Splice Variant

Entrez Gene

66583

UniGene

Mm.289086

RefSeq

NP_079920

MGI ID

MGI Symbol

Exosc1

OMIM

CCDS

CCDS29816

HPRD

IMGT

EMBL

AK002930 AK006018 BC024423

GenPept

AAH24423 BAB22465 BAB24368