InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Pnkd

Summary

InnateDB Protein

IDBP-166612.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Pnkd

Protein Name

paroxysmal nonkinesiogenic dyskinesia

Synonyms

2210013N15Rik; 2810403H05Rik; AI854243; Brp17; MNCb-5687; MR-1; Tahccp2;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000027370

InnateDB Gene

IDBG-166610 (Pnkd)

Protein Structure

UniProt Annotation

Function

Probable hydrolase that plays an aggravative role in the development of cardiac hypertrophy via activation of the NF-kappa- B signaling pathway. {ECO:0000269PubMed:17420335}.

Subcellular Localization

Isoform 1: Membrane; Peripheral membrane protein.Isoform 2: Cytoplasm. Nucleus.Isoform 4: Mitochondrion {ECO:0000250}.

Disease Associations

Tissue Specificity

Expressed in many discrete areas of the brain. {ECO:0000269PubMed:15496428}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003674	molecular_function
GO:0004416	hydroxyacylglutathione hydrolase activity
GO:0008270	zinc ion binding
GO:0016787	hydrolase activity

Biological Process

GO:0006750	glutathione biosynthetic process
GO:0032225	regulation of synaptic transmission, dopaminergic
GO:0042053	regulation of dopamine metabolic process
GO:0050884	neuromuscular process controlling posture