Version 5.4
Mus musculus Protein: Spint2
Summary
InnateDB Protein IDBP-166691.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Spint2
Protein Name serine protease inhibitor, Kunitz type 2
Synonyms AL024025; C76321; HAI-2;
Species Mus musculus
Ensembl Protein ENSMUSP00000096204
InnateDB Gene IDBG-166689 (Spint2)
Protein Structure
UniProt Annotation
Function Inhibitor of HGF activator.
Subcellular Localization Membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.
Disease Associations
Tissue Specificity Isoform 2 is more predominantly expressed than isoform 1.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Predicted by orthology
Total 3 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004867 serine-type endopeptidase inhibitor activity
Biological Process
GO:0010951 negative regulation of endopeptidase activity
Cellular Component
GO:0005737 cytoplasm
GO:0016021 integral component of membrane
Protein Structure and Domains
PDB ID MGI:1338031
InterPro IPR002223 Proteinase inhibitor I2, Kunitz metazoa
PFAM PF00014
PRINTS PR00759
PIRSF
SMART SM00131
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9WU03
PhosphoSite PhosphoSite-Q9WU03
TrEMBL
UniProt Splice Variant
Entrez Gene 20733
UniGene
RefSeq NP_035594
MGI ID
MGI Symbol Spint2
OMIM
CCDS CCDS39870
HPRD
IMGT
EMBL AF099016 AF099019 AF099020 BC003431 BC026419
GenPept AAD22172 AAD22173 AAD22174 AAH03431 AAH26419

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca