InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Psmb7

Summary

InnateDB Protein

IDBP-166734.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Psmb7

Protein Name

proteasome (prosome, macropain) subunit, beta type 7

Synonyms

AU020723; MC14;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000028083

InnateDB Gene

IDBG-166732 (Psmb7)

Protein Structure

UniProt Annotation

Function

The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity. This unit is responsible of the trypsin-like activity of the proteasome (By similarity). {ECO:0000250}.

Subcellular Localization

Cytoplasm. Nucleus.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
They are also associated with 61 interaction(s) predicted by orthology.

Experimentally validated
Total	5 [view]
Protein-Protein	4 [view]
Protein-DNA	0
Protein-RNA	1 [view]
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	61 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004298	threonine-type endopeptidase activity
GO:0005515	protein binding

Biological Process

GO:0051603

proteolysis involved in cellular protein catabolic process

Cellular Component

GO:0005634	nucleus
GO:0005829	cytosol
GO:0005839	proteasome core complex
GO:0015630	microtubule cytoskeleton
GO:0070062	extracellular vesicular exosome

Protein Structure and Domains

PDB ID

MGI:107637

InterPro

IPR000243 Peptidase T1A, proteasome beta-subunit
IPR001353 Proteasome, subunit alpha/beta
IPR024689 Proteasome beta subunit, C-terminal
IPR029055 Nucleophile aminohydrolases, N-terminal

PFAM

PF00227
PF12465

PRINTS

PR00141

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

P70195