InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Ppp1r14a

Summary

InnateDB Protein

IDBP-166737.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Ppp1r14a

Protein Name

protein phosphatase 1, regulatory (inhibitor) subunit 14A

Synonyms

1110001M11Rik; Cpi17;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000035642

InnateDB Gene

IDBG-166735 (Ppp1r14a)

Protein Structure

UniProt Annotation

Function

Inhibitor of PPP1CA. Has over 1000-fold higher inhibitory activity when phosphorylated, creating a molecular switch for regulating the phosphorylation status of PPP1CA substrates and smooth muscle contraction (By similarity). {ECO:0000250}.

Subcellular Localization

Cytoplasm {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 15 interaction(s) predicted by orthology.

Experimentally validated
Total	2 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	15 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004864	protein phosphatase inhibitor activity

Biological Process

GO:0042325	regulation of phosphorylation
GO:0043086	negative regulation of catalytic activity

Cellular Component

GO:0005737

cytoplasm

Protein Structure and Domains

PDB ID

MGI:1931139

InterPro

IPR008025 PKC-activated phosphatase-1 inhibitor

PFAM

PF05361

PRINTS

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q91VC7

PhosphoSite

PhosphoSite-Q91VC7

TrEMBL

UniProt Splice Variant

Entrez Gene

68458

UniGene

Mm.2343

RefSeq

NP_081007

MGI ID

MGI Symbol

Ppp1r14a

OMIM

CCDS

CCDS21070

HPRD

IMGT

EMBL

AF352573 AY050672 BC010832

GenPept

AAH10832 AAK35214 AAL25830