Mus musculus Protein: Gzme
Summary
InnateDB Protein IDBP-166742.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Gzme
Protein Name granzyme E
Synonyms CCP3; Ctla-6; Ctla6; MCSP-2;
Species Mus musculus
Ensembl Protein ENSMUSP00000086978
InnateDB Gene IDBG-166738 (Gzme)
Protein Structure
UniProt Annotation
Function This enzyme is probably necessary for target cell lysis in cell-mediated immune responses.
Subcellular Localization Cytoplasmic granule. Note=Cytoplasmic granules of cytolytic T-lymphocytes.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
Experimentally validated
Total 2 [view]
Protein-Protein 2 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003824 catalytic activity
GO:0004252 serine-type endopeptidase activity
Biological Process
GO:0006508 proteolysis
GO:0019835 cytolysis
Cellular Component
GO:0030141 secretory granule
Protein Structure and Domains
PDB ID MGI:109265
InterPro IPR001254 Peptidase S1
IPR001314 Peptidase S1A, chymotrypsin-type
IPR009003 Trypsin-like cysteine/serine peptidase domain
PFAM PF00089
PRINTS PR00722
PIRSF
SMART SM00020
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt P08884
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 14942
UniGene Mm.14424
RefSeq NP_034503
MGI ID
MGI Symbol Gzme
OMIM
CCDS CCDS27143
HPRD
IMGT
EMBL J03256 M36901 U66474 X12821 X14093 X56988
GenPept AAA37487 AAA37737 AAB19192 CAA31308 CAA32255 CAA40306