InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Dpf1

Summary

InnateDB Protein

IDBP-166772.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Dpf1

Protein Name

D4, zinc and double PHD fingers family 1

Synonyms

Neud4;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000070539

InnateDB Gene

IDBG-166768 (Dpf1)

Protein Structure

UniProt Annotation

Function

May have an important role in developing neurons by participating in regulation of cell survival, possibly as a neurospecific transcription factor. Belongs to the neuron-specific chromatin remodeling complex (nBAF complex). During neural development a switch from a stem/progenitor to a post-mitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to post-mitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth. {ECO:0000269PubMed:17640523}.

Subcellular Localization

Cytoplasm {ECO:0000305}. Nucleus {ECO:0000305}.

Disease Associations

Tissue Specificity

At embryonic stages, predominant expression in the nervous system. Expressed specifically in post-mitotic neurons (at protein level). {ECO:0000269PubMed:17640523}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 10 interaction(s) predicted by orthology.

Predicted by orthology
Total	10 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003676	nucleic acid binding
GO:0005515	protein binding
GO:0008270	zinc ion binding
GO:0046872	metal ion binding

Biological Process

GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0007399	nervous system development

Cellular Component

GO:0005737	cytoplasm
GO:0071565	nBAF complex

Protein Structure and Domains

PDB ID

MGI:1352748

InterPro

IPR001965 Zinc finger, PHD-type
IPR007087 Zinc finger, C2H2
IPR011011 Zinc finger, FYVE/PHD-type
IPR015880 Zinc finger, C2H2-like
IPR019787 Zinc finger, PHD-finger

PFAM

PF00096
PF00628

PRINTS

PIRSF

SMART

SM00249
SM00355

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q9QX66