InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Acsbg1

Summary

InnateDB Protein

IDBP-166844.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Acsbg1

Protein Name

acyl-CoA synthetase bubblegum family member 1

Synonyms

BG1; Bgm; E230019G03Rik; Lpd; mKIAA0631; R75185;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000034822

InnateDB Gene

IDBG-166842 (Acsbg1)

Protein Structure

UniProt Annotation

Function

Mediates activation of long-chain fatty acids for both synthesis of cellular lipids, and degradation via beta-oxidation. Able to activate long-chain fatty acids. Can activate diverse saturated, monosaturated and polyunsaturated fatty acids (By similarity). {ECO:0000250}.

Subcellular Localization

Cytoplasm {ECO:0000250}. Cytoplasmic vesicle. Microsome. Endoplasmic reticulum.

Disease Associations

Tissue Specificity

Mainly expressed in brain. Also expressed in adrenal gland and testis. In brain, it is present in cerebral cortical and cerebellar neurons and in steroidogenic cells of the adrenal gland, testis and ovary (at protein level). {ECO:0000269PubMed:11112418, ECO:0000269PubMed:12975357, ECO:0000269PubMed:14516277, ECO:0000269PubMed:16469493}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003824	catalytic activity
GO:0004467	long-chain fatty acid-CoA ligase activity
GO:0005524	ATP binding
GO:0031957	very long-chain fatty acid-CoA ligase activity

Biological Process

GO:0000038	very long-chain fatty acid metabolic process
GO:0001552	ovarian follicle atresia
GO:0001676	long-chain fatty acid metabolic process
GO:0008152	metabolic process
GO:0051384	response to glucocorticoid