Version 5.4
Mus musculus Protein: Cep72
Summary
InnateDB Protein IDBP-166908.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Cep72
Protein Name centrosomal protein 72
Synonyms 2610029E11Rik; 4933440J22Rik;
Species Mus musculus
Ensembl Protein ENSMUSP00000037788
InnateDB Gene IDBG-166906 (Cep72)
Protein Structure
UniProt Annotation
Function Involved in the recruitment of key centrosomal proteins to the centrosome. Provides centrosomal microtubule-nucleation activity on the gamma-tubulin ring complexes (gamma-TuRCs) and has critical roles in forming a focused bipolar spindle, which is needed for proper tension generation between sister chromatids. Required for localization of KIZ, AKAP9 and gamma-tubulin ring complexes (gamma-TuRCs) (By similarity). {ECO:0000250}.
Subcellular Localization Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Note=Localizes to the centrosome and centrosome-surrounding particles throughout the cell cycle. These particles disappear after microtubules are depolymerized using nocodazole, suggesting that CEP72-associating particles localize in a microtubule- dependent manner (By similarity). {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 13 experimentally validated interaction(s) in this database.
They are also associated with 9 interaction(s) predicted by orthology.
Experimentally validated
Total 13 [view]
Protein-Protein 13 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 9 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0042802 identical protein binding
Biological Process
GO:0007051 spindle organization
GO:0033566 gamma-tubulin complex localization
Cellular Component
GO:0005737 cytoplasm
GO:0005813 centrosome
Protein Structure and Domains
PDB ID MGI:1921720
InterPro IPR003591 Leucine-rich repeat, typical subtype
IPR003603 U2A\'/phosphoprotein 32 family A, C-terminal
PFAM
PRINTS
PIRSF
SMART SM00369
SM00446
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9D3R3
PhosphoSite PhosphoSite-Q9D3R3
TrEMBL
UniProt Splice Variant
Entrez Gene 74470
UniGene Mm.418589
RefSeq NP_083235
MGI ID
MGI Symbol Cep72
OMIM
CCDS CCDS26639
HPRD
IMGT
EMBL AK011607 AK017134 AK034892 AK161033 AK173189 BC100549 CT010471
GenPept AAI00550 BAB27729 BAB30613 BAC28870 BAD32467 BAE36159

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca