InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Ankrd2

Summary

InnateDB Protein

IDBP-166938.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Ankrd2

Protein Name

ankyrin repeat domain 2 (stretch responsive muscle)

Synonyms

Arpp; mArpp;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000026172

InnateDB Gene

IDBG-166936 (Ankrd2)

Protein Structure

UniProt Annotation

Function

Functions as a negative regulator of myocyte differentiation. May interact with both sarcoplasmic structural proteins and nuclear proteins to regulate gene expression during muscle development and in response to muscle stress. {ECO:0000269PubMed:21737686, ECO:0000269PubMed:23824195}.

Subcellular Localization

Cytoplasm, myofibril, sarcomere, I band. Cytoplasm, cytosol. Nucleus. Nucleus, PML body {ECO:0000250}. Note=In the sarcoplasm of differentiated striated muscle cells, where it is cytosolic and enriched in the I band. In nucleus and PML bodies of proliferating and undifferentiated myoblasts. Associates with the euchromatin in the nucleus of myocytes upon muscle stress.

Disease Associations

Tissue Specificity

Expressed by myoblasts (at protein level). Expressed in skeletal and cardiac muscles. {ECO:0000269PubMed:10873377}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 8 interaction(s) predicted by orthology.

Experimentally validated
Total	2 [view]
Protein-Protein	1 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	8 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0031432	titin binding
GO:0043422	protein kinase B binding

Biological Process

GO:0035914	skeletal muscle cell differentiation
GO:0045662	negative regulation of myoblast differentiation

Cellular Component

GO:0000791	euchromatin
GO:0005634	nucleus
GO:0005829	cytosol
GO:0016605	PML body
GO:0030016	myofibril
GO:0030017	sarcomere
GO:0031674	I band
GO:0043231	intracellular membrane-bounded organelle