Version 5.4
Mus musculus Protein: Fcho1
Summary
InnateDB Protein IDBP-166992.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Fcho1
Protein Name FCH domain only 1
Synonyms 3322402E17Rik; N28152;
Species Mus musculus
Ensembl Protein ENSMUSP00000091151
InnateDB Gene IDBG-166990 (Fcho1)
Protein Structure
UniProt Annotation
Function Functions in an early step of clathrin-mediated endocytosis. Has both a membrane binding/bending activity and the ability to recruit proteins essential to the formation of functional clathrin-coated pits. May regulate Bmp signaling by regulating clathrin-mediated endocytosis of Bmp receptors (By similarity). {ECO:0000250}.
Subcellular Localization Membrane, clathrin-coated pit {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Cytoplasmic side {ECO:0000250}. Note=Associated with forming but not mature clathrin-coated vesicles. The recruitment to coated-pits precede the one of clathrin and the adaptor protein complex AP-2 (By similarity). {ECO:0000250}.
Disease Associations
Tissue Specificity Mainly detected in brain and spleen. {ECO:0000269PubMed:21762413}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Experimentally validated
Total 4 [view]
Protein-Protein 4 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 3 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0035612 AP-2 adaptor complex binding
Biological Process
GO:0006886 intracellular protein transport
GO:0016192 vesicle-mediated transport
GO:0048268 clathrin coat assembly
GO:0072583 clathrin-mediated endocytosis
Cellular Component
GO:0005886 plasma membrane
GO:0005905 coated pit
GO:0030131 clathrin adaptor complex
GO:0030136 clathrin-coated vesicle
Protein Structure and Domains
PDB ID MGI:1921265
InterPro IPR001060 FCH domain
IPR008968 Clathrin adaptor, mu subunit, C-terminal
IPR018808 Muniscin C-terminal
PFAM PF00611
PF00928
PF10291
PRINTS
PIRSF
SMART SM00055
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q8K285
PhosphoSite PhosphoSite-Q8K285
TrEMBL D3Z6N2
UniProt Splice Variant
Entrez Gene 74015
UniGene Mm.416596
RefSeq NP_082991
MGI ID
MGI Symbol Fcho1
OMIM
CCDS CCDS52588
HPRD
IMGT
EMBL AC162033 BC032207
GenPept AAH32207

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca