Version 5.4
Mus musculus Protein: Gzmb
Summary
InnateDB Protein IDBP-167003.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Gzmb
Protein Name granzyme B
Synonyms AI553453; CCP-1/C11; CCP1; Ctla-1; Ctla1; GZB;
Species Mus musculus
Ensembl Protein ENSMUSP00000015581
InnateDB Gene IDBG-167001 (Gzmb)
Protein Structure
UniProt Annotation
Function This enzyme is necessary for target cell lysis in cell- mediated immune responses. It cleaves after Asp. Seems to be linked to an activation cascade of caspases (aspartate-specific cysteine proteases) responsible for apoptosis execution. Cleaves caspase-3, -7, -9 and 10 to give rise to active enzymes mediating apoptosis (By similarity). {ECO:0000250}.
Subcellular Localization Cytoplasmic granule. Note=Cytoplasmic granules of cytolytic T-lymphocytes and natural killer cells.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 29 experimentally validated interaction(s) in this database.
They are also associated with 36 interaction(s) predicted by orthology.
Experimentally validated
Total 29 [view]
Protein-Protein 17 [view]
Protein-DNA 11 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 1 [view]
DNA-RNA 0
Predicted by orthology
Total 36 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003824 catalytic activity
GO:0004252 serine-type endopeptidase activity
GO:0005515 protein binding
GO:0008236 serine-type peptidase activity
Biological Process
GO:0001913 T cell mediated cytotoxicity
GO:0006508 proteolysis
GO:0008626 granzyme-mediated apoptotic signaling pathway
GO:0019835 cytolysis
Cellular Component
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0030141 secretory granule
GO:0044194 cytolytic granule
Protein Structure and Domains
PDB ID MGI:109267
InterPro IPR001254 Peptidase S1
IPR001314 Peptidase S1A, chymotrypsin-type
IPR009003 Trypsin-like cysteine/serine peptidase domain
PFAM PF00089
PRINTS PR00722
PIRSF
SMART SM00020
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt P04187
PhosphoSite PhosphoSite-
TrEMBL Q3TZH4
UniProt Splice Variant
Entrez Gene 14939
UniGene Mm.14874
RefSeq NP_038570
MGI ID 2CP1
MGI Symbol Gzmb
OMIM
CCDS CCDS27147
HPRD
IMGT
EMBL AK157856 BC002085 CH466535 M12302 M22526 U05707 X04072
GenPept AAA37383 AAB60470 AAB61756 AAH02085 BAE34234 CAA27715 EDL36202

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca