InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Cyp2d9

Summary

InnateDB Protein

IDBP-167137.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Cyp2d9

Protein Name

cytochrome P450, family 2, subfamily d, polypeptide 9

Synonyms

Cyp2d; P450-2D;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000086530

InnateDB Gene

IDBG-167135 (Cyp2d9)

Protein Structure

UniProt Annotation

Function

Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.

Subcellular Localization

Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005506	iron ion binding
GO:0016705	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
GO:0020037	heme binding
GO:0070330	aromatase activity

Biological Process

GO:0055114

oxidation-reduction process

Cellular Component

GO:0005789

endoplasmic reticulum membrane

Protein Structure and Domains

PDB ID

MGI:88606

InterPro

IPR001128 Cytochrome P450
IPR002401 Cytochrome P450, E-class, group I
IPR002403 Cytochrome P450, E-class, group IV
IPR008069 Cytochrome P450, E-class, group I, CYP2D-like

PFAM

PF00067

PRINTS

PR00385
PR00463
PR00465
PR01686

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

P11714