Mus musculus Protein: Usp37 | |||||||||||
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Summary | |||||||||||
InnateDB Protein | IDBP-167166.6 | ||||||||||
Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||
Gene Symbol | Usp37 | ||||||||||
Protein Name | ubiquitin specific peptidase 37 | ||||||||||
Synonyms | |||||||||||
Species | Mus musculus | ||||||||||
Ensembl Protein | ENSMUSP00000035445 | ||||||||||
InnateDB Gene | IDBG-167164 (Usp37) | ||||||||||
Protein Structure | |||||||||||
UniProt Annotation | |||||||||||
Function | Deubiquitinase that antagonizes the anaphase-promoting complex (APC/C) during G1/S transition by mediating deubiquitination of cyclin-A (CCNA1 and CCNA2), thereby promoting S phase entry. Specifically mediates deubiquitination of 'Lys-11'- linked polyubiquitin chains, a specific ubiquitin-linkage type mediated by the APC/C complex. Also mediates deubiquitination of 'Lys-48'-linked polyubiquitin chains in vitro. Phosphorylation at Ser-628 during G1/S phase maximizes the deubiquitinase activity, leading to prevent degradation of cyclin-A (CCNA1 and CCNA2) (By similarity). {ECO:0000250}. | ||||||||||
Subcellular Localization | |||||||||||
Disease Associations | |||||||||||
Tissue Specificity | |||||||||||
Comments | |||||||||||
Interactions | |||||||||||
Number of Interactions |
This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 17 interaction(s) predicted by orthology.
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Gene Ontology | |||||||||||
Molecular Function |
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Biological Process |
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Cellular Component |
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Protein Structure and Domains | |||||||||||
PDB ID | MGI:2442483 | ||||||||||
InterPro |
IPR001394
Peptidase C19, ubiquitin carboxyl-terminal hydrolase IPR003903 Ubiquitin interacting motif IPR028889 Ubiquitin carboxyl-terminal hydrolase-like domain |
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PFAM |
PF00443
PF02809 |
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PRINTS | |||||||||||
PIRSF | |||||||||||
SMART |
SM00726
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TIGRFAMs | |||||||||||
Post-translational Modifications | |||||||||||
Modification | |||||||||||
Cross-References | |||||||||||
SwissProt | Q8C0R0 | ||||||||||
PhosphoSite | PhosphoSite-Q8C0R0 | ||||||||||
TrEMBL | |||||||||||
UniProt Splice Variant | |||||||||||
Entrez Gene | 319651 | ||||||||||
UniGene | Mm.66568 | ||||||||||
RefSeq | XP_006496121 | ||||||||||
MGI ID | |||||||||||
MGI Symbol | Usp37 | ||||||||||
OMIM | |||||||||||
CCDS | |||||||||||
HPRD | |||||||||||
IMGT | |||||||||||
EMBL | AK030013 AK035640 AK173210 BC139091 | ||||||||||
GenPept | AAI39092 BAC26734 BAC29135 BAD32488 | ||||||||||