InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Rnf17

Summary

InnateDB Protein

IDBP-167171.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Rnf17

Protein Name

ring finger protein 17

Synonyms

MMIP-2; Mmip2; TDRD4;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000093469

InnateDB Gene

IDBG-167169 (Rnf17)

Protein Structure

UniProt Annotation

Function

Seems to be involved in regulation of transcriptional activity of MYC. In vitro, inhibits DNA-binding activity of Mad- MAX heterodimers. Can recruit Mad transcriptional repressors (MXD1, MXD3, MXD4 and MXI1) to the cytoplasm. May be involved in spermiogenesis. {ECO:0000269PubMed:10597267, ECO:0000269PubMed:11420703}.

Subcellular Localization

Cytoplasm. Nucleus. Note=Predominantly found in the cytoplasm. Component of a nuage in male germ cells (an electron-dense spherical cytoplasmic body present in late pachytene and diplotene spermatocytes and in elonging spermatids).

Disease Associations

Tissue Specificity

Expressed at high levels in adult testis. Expressed in male germ cells (at protein level). Expressed at lower levels in adult thyroid, submaxillary gland, ovary and epididymis. {ECO:0000269PubMed:10597267, ECO:0000269PubMed:16093322}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	2 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003676	nucleic acid binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0004871	signal transducer activity
GO:0005515	protein binding
GO:0008270	zinc ion binding
GO:0016788	hydrolase activity, acting on ester bonds
GO:0042803	protein homodimerization activity

Biological Process

GO:0006355	regulation of transcription, DNA-templated
GO:0007165	signal transduction
GO:0007275	multicellular organismal development
GO:0007286	spermatid development
GO:0008152	metabolic process

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm

Protein Structure and Domains

PDB ID

MGI:1353419

InterPro

IPR001841 Zinc finger, RING-type
IPR002999 Tudor domain
IPR015988 STAT transcription factor, coiled coil
IPR016071 Staphylococcal nuclease (SNase-like), OB-fold

PFAM

PF13639
PF14634
PF00567
PF00565

PRINTS

PIRSF

SMART

SM00184
SM00333
SM00318

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q99MV7