Version 5.4
Mus musculus Protein: Scai
Summary
InnateDB Protein IDBP-167271.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Scai
Protein Name suppressor of cancer cell invasion
Synonyms
Species Mus musculus
Ensembl Protein ENSMUSP00000037194
InnateDB Gene IDBG-167269 (Scai)
Protein Structure
UniProt Annotation
Function Tumor suppressor which functions to suppress MKL1- induced SRF transcriptional activity. May function in the RHOA- DIAPH1 signal transduction pathway and regulate cell migration through transcriptional regulation of ITGB1. {ECO:0000269PubMed:19350017}.
Subcellular Localization Membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}. Nucleus {ECO:0000269PubMed:19350017}. Cytoplasm {ECO:0000269PubMed:19350017}. Note=Nuclear localization is required for inhibition of MKL1.
Disease Associations
Tissue Specificity Expressed in most tissues tested with higher expression levels in brain, spleen and thymus. {ECO:0000269PubMed:19350017}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003714 transcription corepressor activity
GO:0005515 protein binding
Biological Process
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0030336 negative regulation of cell migration
GO:0035024 negative regulation of Rho protein signal transduction
GO:2001141 regulation of RNA biosynthetic process
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0016021 integral component of membrane
Protein Structure and Domains
PDB ID MGI:2443716
InterPro IPR016607 Protein SCAI, metazoan/viridiplantae
IPR022709 Protein SCAI
PFAM PF12070
PRINTS
PIRSF PIRSF013022
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q8C8N2
PhosphoSite PhosphoSite-Q8C8N2
TrEMBL B0R0E3
UniProt Splice Variant
Entrez Gene 320271
UniGene Mm.204836
RefSeq NP_848893
MGI ID
MGI Symbol Scai
OMIM
CCDS CCDS38121
HPRD
IMGT
EMBL AK044772 AK046875 AK083280 AL844588 AL845350 AL928639 BC132485 CH466519
GenPept AAI32486 BAC32081 BAC32904 BAC38841 CAM46058 CAO77724 CAQ11836 EDL26843

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca