Version 5.4
Mus musculus Protein: Zfyve27
Summary
InnateDB Protein IDBP-167294.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Zfyve27
Protein Name zinc finger, FYVE domain containing 27
Synonyms
Species Mus musculus
Ensembl Protein ENSMUSP00000097042
InnateDB Gene IDBG-167290 (Zfyve27)
Protein Structure
UniProt Annotation
Function Functions as an upstream inhibitor of RAB11, regulating directional protein transport to the forming neurites. Involved in nerve growth factor-induced neurite formation. May have a more general role in cell projections formation (By similarity). {ECO:0000250}.
Subcellular Localization Recycling endosome membrane {ECO:0000305PubMed:17082457}; Multi-pass membrane protein {ECO:0000305PubMed:17082457}. Endoplasmic reticulum membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Cell projection, growth cone membrane {ECO:0000269PubMed:17082457}; Multi-pass membrane protein {ECO:0000269PubMed:17082457}. Cell membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Note=Localizes at both dendrites and axons.
Disease Associations
Tissue Specificity Most abundant in cerebrum and cerebellum. Also detected in heart, thymus, spleen, intestine and lung. {ECO:0000269PubMed:17082457}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 6 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0046872 metal ion binding
Biological Process
GO:0031175 neuron projection development
GO:0048011 neurotrophin TRK receptor signaling pathway
GO:0072659 protein localization to plasma membrane
Cellular Component
GO:0005737 cytoplasm
GO:0005783 endoplasmic reticulum
GO:0005789 endoplasmic reticulum membrane
GO:0016021 integral component of membrane
GO:0030424 axon
GO:0030425 dendrite
GO:0032584 growth cone membrane
GO:0055038 recycling endosome membrane
Protein Structure and Domains
PDB ID MGI:1919602
InterPro IPR000306 FYVE zinc finger
IPR011011 Zinc finger, FYVE/PHD-type
IPR017455 Zinc finger, FYVE-related
PFAM PF01363
PRINTS
PIRSF
SMART SM00064
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q3TXX3
PhosphoSite PhosphoSite-Q3TXX3
TrEMBL E9Q4U6
UniProt Splice Variant
Entrez Gene 319740
UniGene Mm.490064
RefSeq NP_001158003
MGI ID
MGI Symbol Zfyve27
OMIM
CCDS CCDS50440
HPRD
IMGT
EMBL AK159065 AL603804 BC042595
GenPept AAH42595 BAE34791

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca