InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Plcd4

Summary

InnateDB Protein

IDBP-167414.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Plcd4

Protein Name

phospholipase C, delta 4

Synonyms

4921507K24Rik;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000064413

InnateDB Gene

IDBG-167412 (Plcd4)

Protein Structure

UniProt Annotation

Function

Hydrolyzes the phosphatidylinositol 4,5-bisphosphate (PIP2) to generate 2 second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). DAG mediates the activation of protein kinase C (PKC), while IP3 releases Ca(2+) from intracellular stores. Required for acrosome reaction in sperm during fertilization, probably by acting as an important enzyme for intracellular Ca(2+) mobilization in the zona pellucida- induced acrosome reaction. May play a role in cell growth. Modulates the liver regeneration in cooperation with nuclear PKC. Overexpression up-regulates the Erk signaling pathway and proliferation. {ECO:0000269PubMed:11340203, ECO:0000269PubMed:12695499, ECO:0000269PubMed:16998201}.

Subcellular Localization

Membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Nucleus {ECO:0000250}. Cytoplasm {ECO:0000250}. Endoplasmic reticulum {ECO:0000250}. Note=Localizes primarily to intracellular membranes mostly to the endoplasmic reticulum. {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004435	phosphatidylinositol phospholipase C activity
GO:0004629	phospholipase C activity
GO:0004871	signal transducer activity
GO:0005509	calcium ion binding
GO:0005515	protein binding
GO:0008081	phosphoric diester hydrolase activity

Biological Process

GO:0006629	lipid metabolic process
GO:0007165	signal transduction
GO:0007340	acrosome reaction
GO:0016042	lipid catabolic process
GO:0035556	intracellular signal transduction
GO:0046488	phosphatidylinositol metabolic process

Cellular Component

GO:0005622	intracellular
GO:0005634	nucleus
GO:0005783	endoplasmic reticulum
GO:0016020	membrane

Protein Structure and Domains

PDB ID

MGI:107469

InterPro

IPR000008 C2 domain
IPR000909 Phospholipase C, phosphatidylinositol-specific , X domain
IPR001192 Phosphoinositide phospholipase C family
IPR001711 Phospholipase C, phosphatidylinositol-specific, Y domain
IPR001849 Pleckstrin homology domain
IPR002048 EF-hand domain
IPR015359 Phospholipase C, phosphoinositol-specific, EF-hand-like
IPR017946 PLC-like phosphodiesterase, TIM beta/alpha-barrel domain

PFAM