InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Tpm4

Summary

InnateDB Protein

IDBP-167422.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Tpm4

Protein Name

tropomyosin 4

Synonyms

Species

Mus musculus

Ensembl Protein

ENSMUSP00000003575

InnateDB Gene

IDBG-167420 (Tpm4)

Protein Structure

UniProt Annotation

Function

Binds to actin filaments in muscle and non-muscle cells. Plays a central role, in association with the troponin complex, in the calcium dependent regulation of vertebrate striated muscle contraction. Smooth muscle contraction is regulated by interaction with caldesmon. In non-muscle cells is implicated in stabilizing cytoskeleton actin filaments. Binds calcium (By similarity). {ECO:0000250}.

Subcellular Localization

Cytoplasm, cytoskeleton {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.

Experimentally validated
Total	3 [view]
Protein-Protein	3 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003674	molecular_function
GO:0003779	actin binding
GO:0046872	metal ion binding

Biological Process

GO:0001649

osteoblast differentiation

Cellular Component

GO:0001725	stress fiber
GO:0002102	podosome
GO:0005737	cytoplasm
GO:0016020	membrane
GO:0030863	cortical cytoskeleton
GO:0031941	filamentous actin
GO:0070062	extracellular vesicular exosome