Version 5.4
Mus musculus Protein: Cenpj
Summary
InnateDB Protein IDBP-167425.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Cenpj
Protein Name centromere protein J
Synonyms
Species Mus musculus
Ensembl Protein ENSMUSP00000065949
InnateDB Gene IDBG-167423 (Cenpj)
Protein Structure
UniProt Annotation
Function Plays an important role in cell division and centrosome function by participating in centriole duplication. Inhibits microtubule nucleation from the centrosome (By similarity). {ECO:0000250}.
Subcellular Localization Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000250}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole {ECO:0000250}. Note=Localized within the center of microtubule asters. During centriole biogenesis, it is concentrated within the proximal lumen of both parental centrioles and procentrioles (By similarity). {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 11 interaction(s) predicted by orthology.
Experimentally validated
Total 2 [view]
Protein-Protein 1 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 11 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0015631 tubulin binding
GO:0019901 protein kinase binding
GO:0019904 protein domain specific binding
Biological Process
GO:0007099 centriole replication
GO:0046599 regulation of centriole replication
GO:0046785 microtubule polymerization
Cellular Component
GO:0005813 centrosome
GO:0005814 centriole
GO:0005874 microtubule
Protein Structure and Domains
PDB ID MGI:2684927
InterPro IPR009852 T-complex protein 10, C-terminal domain
PFAM PF07202
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q569L8
PhosphoSite PhosphoSite-Q569L8
TrEMBL
UniProt Splice Variant
Entrez Gene 219103
UniGene Mm.395431
RefSeq NP_001014996
MGI ID
MGI Symbol Cenpj
OMIM
CCDS CCDS27150
HPRD
IMGT
EMBL AC154837 BC092399
GenPept AAH92399

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca