InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Ilf2

Summary

InnateDB Protein

IDBP-167428.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Ilf2

Protein Name

interleukin enhancer binding factor 2

Synonyms

6230405A16Rik; TEG-267; Tex261; Tex267;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000001042

InnateDB Gene

IDBG-167426 (Ilf2)

Protein Structure

UniProt Annotation

Function

Appears to function predominantly as a heterodimeric complex with ILF3. This complex may regulate transcription of the IL2 gene during T-cell activation. It can also promote the formation of stable DNA-dependent protein kinase holoenzyme complexes on DNA (By similarity). Essential for the efficient reshuttling of ILF3 into the nucleus (By similarity). {ECO:0000250}.

Subcellular Localization

Nucleus, nucleolus {ECO:0000269PubMed:11804788}. Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}. Note=Localized in cytoplasmic mRNP granules containing untranslated mRNAs. {ECO:0000250}.

Disease Associations

Tissue Specificity

Expressed in brain, kidney and ovary; highly expressed in testis, particularly within pachytene cells. {ECO:0000269PubMed:11804788}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 10 experimentally validated interaction(s) in this database.
They are also associated with 148 interaction(s) predicted by orthology.

Experimentally validated
Total	10 [view]
Protein-Protein	10 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	148 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0003723	RNA binding
GO:0003725	double-stranded RNA binding
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016740	transferase activity
GO:0044822	poly(A) RNA binding