Version 5.4
Mus musculus Protein: Lpar4
Summary
InnateDB Protein IDBP-167434.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Lpar4
Protein Name lysophosphatidic acid receptor 4
Synonyms 5730485F04Rik; Gpr23; LPA4; p2y9;
Species Mus musculus
Ensembl Protein ENSMUSP00000053986
InnateDB Gene IDBG-167432 (Lpar4)
Protein Structure
UniProt Annotation
Function Receptor for lysophosphatidic acid (LPA), a mediator of diverse cellular activities. Transduces a signal by increasing the intracellular calcium ions and by stimulating adenylyl cyclase activity. The rank order of potency for agonists of this receptor is 1-oleoyl- > 1-stearoyl- > 1-palmitoyl- > 1-myristoyl- > 1- alkyl- > 1-alkenyl-LPA (By similarity). {ECO:0000250}.
Subcellular Localization Cell membrane; Multi-pass membrane protein.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004930 G-protein coupled receptor activity
GO:0008289 lipid binding
Biological Process
GO:0007186 G-protein coupled receptor signaling pathway
Cellular Component
GO:0005886 plasma membrane
GO:0016021 integral component of membrane
Protein Structure and Domains
PDB ID MGI:1925384
InterPro IPR000276 G protein-coupled receptor, rhodopsin-like
IPR017452 GPCR, rhodopsin-like, 7TM
IPR019424 7TM GPCR, olfactory receptor/chemoreceptor Srsx
PFAM PF00001
PF10320
PRINTS PR00237
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q8BLG2
PhosphoSite PhosphoSite-
TrEMBL Q80UD5
UniProt Splice Variant
Entrez Gene 78134
UniGene Mm.90147
RefSeq NP_780480
MGI ID
MGI Symbol Lpar4
OMIM
CCDS CCDS30345
HPRD
IMGT
EMBL AK045289 AK051709 AL670943 AY255540 BC019743 BC138893 BC138894 CH466564
GenPept AAH19743 AAI38894 AAI38895 AAO85052 BAC32299 BAC34729 CAM18227 EDL14046

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca