InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Cyp2d26

Summary

InnateDB Protein

IDBP-167463.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Cyp2d26

Protein Name

cytochrome P450, family 2, subfamily d, polypeptide 26

Synonyms

1300006E06Rik;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000006094

InnateDB Gene

IDBG-167461 (Cyp2d26)

Protein Structure

UniProt Annotation

Function

Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics (By similarity). {ECO:0000250UniProtKB:P10634}.

Subcellular Localization

Endoplasmic reticulum membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Microsome membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.

Experimentally validated
Total	6 [view]
Protein-Protein	6 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005506	iron ion binding
GO:0016705	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
GO:0020037	heme binding
GO:0070330	aromatase activity

Biological Process

GO:0007565	female pregnancy
GO:0042493	response to drug
GO:0055114	oxidation-reduction process

Cellular Component

GO:0005789	endoplasmic reticulum membrane
GO:0043231	intracellular membrane-bounded organelle

Protein Structure and Domains

PDB ID

MGI:1923529

InterPro

IPR001128 Cytochrome P450
IPR002401 Cytochrome P450, E-class, group I
IPR002403 Cytochrome P450, E-class, group IV
IPR008069 Cytochrome P450, E-class, group I, CYP2D-like

PFAM

PF00067

PRINTS

PR00385
PR00463
PR00465
PR01686

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q8CIM7