InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Dnajc6

Summary

InnateDB Protein

IDBP-167509.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Dnajc6

Protein Name

DnaJ (Hsp40) homolog, subfamily C, member 6

Synonyms

2810027M23Rik; mKIAA0473;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000044251

InnateDB Gene

IDBG-167507 (Dnajc6)

Protein Structure

UniProt Annotation

Function

Recruits HSPA8/HSC70 to clathrin-coated vesicles and promotes uncoating of clathrin-coated vesicles. Plays a role in clathrin-mediated endocytosis in neurons. {ECO:0000269PubMed:20160091}.

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003674	molecular_function
GO:0004725	protein tyrosine phosphatase activity
GO:0005515	protein binding
GO:0016791	phosphatase activity
GO:0017124	SH3 domain binding

Biological Process

GO:0016311	dephosphorylation
GO:0035335	peptidyl-tyrosine dephosphorylation
GO:0072318	clathrin coat disassembly
GO:2000369	regulation of clathrin-mediated endocytosis

Cellular Component

GO:0045202

synapse

Protein Structure and Domains

PDB ID

MGI:1919935

InterPro

IPR000008 C2 domain
IPR000387 Protein-tyrosine/Dual specificity phosphatase
IPR001623 DnaJ domain
IPR014020 Tensin phosphatase, C2 domain
IPR029021 Protein-tyrosine phosphatase-like
IPR029023 Tensin phosphatase, lipid phosphatase domain

PFAM

PF00168
PF00226
PF10409

PRINTS

PR00360
PR00625

PIRSF

SMART

SM00239
SM00271

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt