InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Serpina1a

Summary

InnateDB Protein

IDBP-167540.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Serpina1a

Protein Name

serine (or cysteine) peptidase inhibitor, clade A, member 1A

Synonyms

Aat-2; Aat2; Dom1; PI1; Spi1-1; Spi1-3;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000082132

InnateDB Gene

IDBG-167538 (Serpina1a)

Protein Structure

UniProt Annotation

Function

Inhibitor of serine proteases. Its primary target is elastase, but it also has a moderate affinity for plasmin and thrombin. {ECO:0000269PubMed:11961105, ECO:0000269PubMed:8619829}.

Subcellular Localization

Secreted {ECO:0000269PubMed:11961105, ECO:0000269PubMed:8619829}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 14 experimentally validated interaction(s) in this database.
They are also associated with 26 interaction(s) predicted by orthology.

Experimentally validated
Total	14 [view]
Protein-Protein	14 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	26 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004867	serine-type endopeptidase inhibitor activity
GO:0005515	protein binding

Biological Process

GO:0006487	protein N-linked glycosylation
GO:0006953	acute-phase response
GO:0010951	negative regulation of endopeptidase activity
GO:0030162	regulation of proteolysis
GO:0034097	response to cytokine
GO:0043434	response to peptide hormone