InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Krtap12-1

Summary

InnateDB Protein

IDBP-167579.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Krtap12-1

Protein Name

keratin associated protein 12-1

Synonyms

D10Jhu14e;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000090024

InnateDB Gene

IDBG-167577 (Krtap12-1)

Protein Structure

UniProt Annotation

Function

In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high- sulfur and high-glycine-tyrosine keratins (By similarity). {ECO:0000250UniProtKB:P59990}.

Subcellular Localization

Disease Associations

Tissue Specificity

Expressed only in the head and back skin of a 3 day old mouse. Not expressed in adult skin. {ECO:0000269PubMed:9878246}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003674	molecular_function

Biological Process

GO:0008150

biological_process

Cellular Component

GO:0045095

keratin filament

Protein Structure and Domains

PDB ID

MGI:1328315

InterPro

PFAM

PRINTS

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q9Z287

PhosphoSite

PhosphoSite-

TrEMBL

UniProt Splice Variant

Entrez Gene

16694

UniGene

Mm.34372

RefSeq

NP_034800

MGI ID

MGI Symbol

Krtap12-1

OMIM

CCDS

CCDS23959

HPRD

IMGT

EMBL

AF081797 BC107319 BC107320 CH466553

GenPept

AAD11776 AAI07320 AAI07321 EDL31791