InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Nfam1

Summary

InnateDB Protein

IDBP-167589.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Nfam1

Protein Name

Nfat activating molecule with ITAM motif 1

Synonyms

4921501M20Rik; Cnaip;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000097946

InnateDB Gene

IDBG-167585 (Nfam1)

Protein Structure

UniProt Annotation

Function

May function in immune system as a receptor which activates via the calcineurin/NFAT-signaling pathway the downstream cytokine gene promoters. Activates the transcription of IL-13 and TNF-alpha promoters (By similarity). May be involved in the regulation of B-cell, but not T-cell, development. {ECO:0000250}.

Subcellular Localization

Cell membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}. Note=Partially recruited to lipid rafts upon BCR stimulation. {ECO:0000250}.

Disease Associations

Tissue Specificity

Highly expressed in the spleen, expressed by both B- and CD4+ and CD8+ T-cells, as well as non-T- and non-B- cells, including macrophages and neutrophils. Expressed at low levels, if any, in non-immune tissue. {ECO:0000269PubMed:15143214}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.

Experimentally validated
Total	4 [view]
Protein-Protein	4 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004888	transmembrane signaling receptor activity

Biological Process

GO:0007165	signal transduction
GO:0030183	B cell differentiation
GO:0035556	intracellular signal transduction
GO:0045577	regulation of B cell differentiation
GO:0050853	B cell receptor signaling pathway
GO:0050861	positive regulation of B cell receptor signaling pathway
GO:0051091	positive regulation of sequence-specific DNA binding transcription factor activity