Version 5.4
Mus musculus Protein: Leprot
Summary
InnateDB Protein IDBP-167698.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Leprot
Protein Name leptin receptor overlapping transcript
Synonyms
Species Mus musculus
Ensembl Protein ENSMUSP00000030254
InnateDB Gene IDBG-167696 (Leprot)
Protein Structure
UniProt Annotation
Function Negatively regulates leptin receptor (LEPR) cell surface expression, and thus decreases response to leptin. Negatively regulates growth hormone (GH) receptor cell surface expression in liver. May play a role in liver resistance to GH during periods of reduced nutrient availability. {ECO:0000269PubMed:18042720, ECO:0000269PubMed:19907080}.
Subcellular Localization Golgi apparatus membrane {ECO:0000269PubMed:18042720}; Multi-pass membrane protein {ECO:0000269PubMed:18042720}. Endosome membrane {ECO:0000269PubMed:18042720}.
Disease Associations
Tissue Specificity Widely distributed in the brain, with elevated expression in the hypothalamic regions, including the paraventricular nucleus. In the placenta, present at high levels in the junctional zone situated towards the maternal aspect and throughout the labyrinth zone in close proximity to the developing fetus. {ECO:0000269PubMed:10849209}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005102 receptor binding
GO:0005515 protein binding
Biological Process
GO:0046426 negative regulation of JAK-STAT cascade
GO:0060400 negative regulation of growth hormone receptor signaling pathway
GO:2000009 negative regulation of protein localization to cell surface
Cellular Component
GO:0000139 Golgi membrane
GO:0010008 endosome membrane
GO:0016021 integral component of membrane
Protein Structure and Domains
PDB ID MGI:2687005
InterPro IPR007262 Vacuolar protein sorting 55
PFAM PF04133
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt O89013
PhosphoSite PhosphoSite-
TrEMBL Q8BTS6
UniProt Splice Variant
Entrez Gene 230514
UniGene Mm.4756
RefSeq NP_778201
MGI ID
MGI Symbol Leprot
OMIM
CCDS CCDS18396
HPRD
IMGT
EMBL AJ011565 AK009569 AK088848 AK159489 AK160453 AK165821 AK168597 AL929373 BC004744 BC010289 BX323551
GenPept AAH04744 AAH10289 BAB26366 BAC40610 BAE35124 BAE35795 BAE38395 BAE40464 CAA09693 CAM16149 CAM16150 CAM20697 CAM20698

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca