InnateDB Protein
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IDBP-167755.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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Serpina12
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Protein Name
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serine (or cysteine) peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 12
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Synonyms
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4632419J12Rik;
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Species
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Mus musculus
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Ensembl Protein
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ENSMUSP00000045572
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InnateDB Gene
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IDBG-167753 (Serpina12)
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Protein Structure
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Function |
Adipokine that modulates insulin action by specifically inhibiting its target protease KLK7 in white adipose tissues. {ECO:0000269PubMed:16030142, ECO:0000269PubMed:23370777}.
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Subcellular Localization |
Secreted {ECO:0000269PubMed:23370777}.
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Disease Associations |
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Tissue Specificity |
Expressed in visceral adipose tissues. {ECO:0000269PubMed:16030142}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
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Predicted by orthology |
Total |
2 [view]
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Molecular Function |
Accession |
GO Term |
GO:0004867
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serine-type endopeptidase inhibitor activity
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Biological Process |
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Cellular Component |
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PDB ID |
MGI:1915304
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InterPro |
IPR023796
Serpin domain
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PFAM |
PF00079
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PRINTS |
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PIRSF |
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SMART |
SM00093
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TIGRFAMs |
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Modification |
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SwissProt |
Q7TMF5
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PhosphoSite |
PhosphoSite-
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
68054
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UniGene |
Mm.20286
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RefSeq |
NP_080811
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MGI ID |
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MGI Symbol |
Serpina12
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OMIM |
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CCDS |
CCDS26145
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HPRD |
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IMGT |
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EMBL |
AK014346
AK014589
AY326419
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GenPept |
AAP88383
BAB29287
BAB29447
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