Version 5.4
Mus musculus Protein: Poldip3
Summary
InnateDB Protein IDBP-167792.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Poldip3
Protein Name polymerase (DNA-directed), delta interacting protein 3
Synonyms 1110008P04Rik; AA408269; AL022852; C77954; mKIAA1649; PDIP46; SKAR;
Species Mus musculus
Ensembl Protein ENSMUSP00000054548
InnateDB Gene IDBG-167790 (Poldip3)
Protein Structure
UniProt Annotation
Function Is involved in regulation of translation. Is preferentially associated with CBC-bound spliced mRNA-protein complexes during the pioneer round of mRNA translation. Contributes to enhanced translational efficiency of spliced over nonspliced mRNAs. Recruits activated ribosomal protein S6 kinase beta-1 I/RPS6KB1 to newly synthesized mRNA. Involved in nuclear mRNA export; probably mediated by assoociation with the TREX complex (By similarity). {ECO:0000250}.
Subcellular Localization Nucleus {ECO:0000250}. Nucleus speckle {ECO:0000250}. Cytoplasm {ECO:0000250}. Note=Nucleocytoplasmic shuttling protein. {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.
They are also associated with 15 interaction(s) predicted by orthology.
Experimentally validated
Total 8 [view]
Protein-Protein 8 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 15 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000166 nucleotide binding
GO:0003676 nucleic acid binding
GO:0003723 RNA binding
Biological Process
GO:0016973 poly(A)+ mRNA export from nucleus
GO:0045727 positive regulation of translation
Cellular Component
GO:0000346 transcription export complex
GO:0005737 cytoplasm
GO:0016607 nuclear speck
GO:0035145 exon-exon junction complex
Protein Structure and Domains
PDB ID MGI:1921076
InterPro IPR000504 RNA recognition motif domain
PFAM PF00076
PRINTS
PIRSF
SMART SM00360
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q8BG81
PhosphoSite PhosphoSite-Q8BG81
TrEMBL Q571G8
UniProt Splice Variant
Entrez Gene 73826
UniGene Mm.406268
RefSeq NP_848742
MGI ID
MGI Symbol Poldip3
OMIM
CCDS CCDS27697
HPRD
IMGT
EMBL AK081139 AK083924 AK087446 AK220221 AL591952 BC037652 BC046505 BC058225
GenPept AAH37652 AAH46505 AAH58225 BAC38144 BAC39068 BAC39877 BAD90146 CAQ51827

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca