Version 5.4
Mus musculus Protein: Rnf25
Summary
InnateDB Protein IDBP-167811.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Rnf25
Protein Name ring finger protein 25
Synonyms 0610009H16Rik; AO7;
Species Mus musculus
Ensembl Protein ENSMUSP00000027357
InnateDB Gene IDBG-167809 (Rnf25)
Protein Structure
UniProt Annotation
Function E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of NKD2. Stimulates transcription mediated by NF-kappa-B (By similarity). {ECO:0000250}.
Subcellular Localization
Disease Associations
Tissue Specificity Ubiquitous. {ECO:0000269PubMed:10500182}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.
They are also associated with 11 interaction(s) predicted by orthology.
Experimentally validated
Total 7 [view]
Protein-Protein 7 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 11 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004842 ubiquitin-protein transferase activity
GO:0005515 protein binding
GO:0008270 zinc ion binding
GO:0016874 ligase activity
GO:0051059 NF-kappaB binding
Biological Process
GO:0016567 protein ubiquitination
GO:0051092 positive regulation of NF-kappaB transcription factor activity
Cellular Component
GO:0005634 nucleus
GO:0005829 cytosol
Protein Structure and Domains
PDB ID MGI:1890215
InterPro IPR001841 Zinc finger, RING-type
IPR006575 RWD domain
IPR016135 Ubiquitin-conjugating enzyme/RWD-like
PFAM PF13639
PF14634
PF05773
PRINTS
PIRSF
SMART SM00184
SM00591
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9QZR0
PhosphoSite PhosphoSite-Q9QZR0
TrEMBL Q9CT51
UniProt Splice Variant
Entrez Gene 57751
UniGene Mm.468417
RefSeq NP_067288
MGI ID
MGI Symbol Rnf25
OMIM
CCDS CCDS15052
HPRD
IMGT
EMBL AC117610 AF171060 AK002399 AK011171 AK171752 BC022715 BC048821
GenPept AAD48057 AAH22715 AAH48821 BAB22071 BAB27445 BAE42650

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca