InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Klf2

Summary

InnateDB Protein

IDBP-167843.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Klf2

Protein Name

Kruppel-like factor 2 (lung)

Synonyms

Lklf;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000064823

InnateDB Gene

IDBG-167841 (Klf2)

Protein Structure

UniProt Annotation

Function

Binds to the CACCC box in the beta-globin gene promoter and activates transcription.

Subcellular Localization

Nucleus {ECO:0000250}.

Disease Associations

Tissue Specificity

Predominant expression in the lungs and spleen.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
They are also associated with 8 interaction(s) predicted by orthology.

Experimentally validated
Total	5 [view]
Protein-Protein	2 [view]
Protein-DNA	3 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	8 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0005515	protein binding
GO:0043565	sequence-specific DNA binding
GO:0046872	metal ion binding

Biological Process

GO:0000902	cell morphogenesis
GO:0001701	in utero embryonic development
GO:0006351	transcription, DNA-templated
GO:0032715	negative regulation of interleukin-6 production
GO:0034101	erythrocyte homeostasis
GO:0034616	response to laminar fluid shear stress
GO:0035264	multicellular organism growth
GO:0036003	positive regulation of transcription from RNA polymerase II promoter in response to stress
GO:0040029	regulation of gene expression, epigenetic
GO:0043249	erythrocyte maturation
GO:0045893	positive regulation of transcription, DNA-templated
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0051247	positive regulation of protein metabolic process
GO:0060509	Type I pneumocyte differentiation
GO:0070301	cellular response to hydrogen peroxide
GO:0071347	cellular response to interleukin-1
GO:0071356	cellular response to tumor necrosis factor
GO:0071407	cellular response to organic cyclic compound
GO:0071409	cellular response to cycloheximide
GO:0071499	cellular response to laminar fluid shear stress
GO:1901653	cellular response to peptide