Version 5.4
Mus musculus Protein: Pspc1
Summary
InnateDB Protein IDBP-167853.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Pspc1
Protein Name paraspeckle protein 1
Synonyms 5730470C09Rik; AI327109; AI449052; PSP1;
Species Mus musculus
Ensembl Protein ENSMUSP00000022507
InnateDB Gene IDBG-167851 (Pspc1)
Protein Structure
UniProt Annotation
Function Together with NONO, required for the formation of nuclear paraspeckles. Regulates, cooperatively with NONO and SFPQ, androgen receptor-mediated gene transcription activity in Sertoli cell line. Binds to poly(A), poly(G) and poly(U) RNA homopolymers. Regulates the circadian clock by repressing the transcriptional activator activity of the CLOCK-ARNTL/BMAL1 heterodimer. {ECO:0000269PubMed:16641145, ECO:0000269PubMed:22966205}.
Subcellular Localization Nucleus, nucleolus {ECO:0000250}. Note=In punctate subnuclear structures localized adjacent to nuclear splicing speckles, called paraspeckles. Colocalizes with NONO and SFPQ in paraspeckles and perinucleolar caps in an RNA-dependent manner. May cycle between paraspeckles and nucleolus. In telophase, when daughter nuclei form, localizes to perinucleolar caps. {ECO:0000250}.Isoform 1: Nucleus matrix. Cytoplasm. Nucleus speckle {ECO:0000250}.
Disease Associations
Tissue Specificity Isoform 1 is strongly expressed in testis (leptoten spermatocytes, round spematids and Sertoli cells) and moderately in cerebrum, cerebellum, lung, spleen and ovary (at protein level). Isoform 2 is strongly expressed in kidney and moderately in salivary gland (at protein level). {ECO:0000269PubMed:15140795, ECO:0000269PubMed:16641145}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 9 experimentally validated interaction(s) in this database.
They are also associated with 16 interaction(s) predicted by orthology.
Experimentally validated
Total 9 [view]
Protein-Protein 9 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 16 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000166 nucleotide binding
GO:0003676 nucleic acid binding
GO:0003723 RNA binding
GO:0005515 protein binding
GO:0044822 poly(A) RNA binding
Biological Process
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005730 nucleolus
GO:0005737 cytoplasm
GO:0016363 nuclear matrix
GO:0016607 nuclear speck
GO:0042382 paraspeckles
Protein Structure and Domains
PDB ID MGI:1913895
InterPro IPR000504 RNA recognition motif domain
IPR012975 NOPS
PFAM PF00076
PF08075
PRINTS
PIRSF
SMART SM00360
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q8R326
PhosphoSite PhosphoSite-Q8R326
TrEMBL
UniProt Splice Variant
Entrez Gene 66645
UniGene Mm.412298
RefSeq NP_079958
MGI ID
MGI Symbol Pspc1
OMIM
CCDS CCDS27151
HPRD
IMGT
EMBL AK011272 AK017689 AK150823 AK160722 BC026772
GenPept AAH26772 BAB27509 BAB30876 BAE29885 BAE35969

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca