InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Kynu

Summary

InnateDB Protein

IDBP-167888.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Kynu

Protein Name

kynureninase (L-kynurenine hydrolase)

Synonyms

4432411A05Rik;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000028223

InnateDB Gene

IDBG-167886 (Kynu)

Protein Structure

UniProt Annotation

Function

Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively. Has a preference for the L-3-hydroxy form. Also has cysteine-conjugate-beta-lyase activity. {ECO:0000255HAMAP-Rule:MF_03017}.

Subcellular Localization

Cytoplasm {ECO:0000255HAMAP-Rule:MF_03017}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 14 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	0
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	14 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0030170	pyridoxal phosphate binding
GO:0030429	kynureninase activity
GO:0042803	protein homodimerization activity

Biological Process

GO:0006569	tryptophan catabolic process
GO:0008152	metabolic process
GO:0009435	NAD biosynthetic process
GO:0019441	tryptophan catabolic process to kynurenine
GO:0019442	tryptophan catabolic process to acetyl-CoA
GO:0019805	quinolinate biosynthetic process
GO:0034341	response to interferon-gamma
GO:0034354	'de novo' NAD biosynthetic process from tryptophan
GO:0034516	response to vitamin B6
GO:0043420	anthranilate metabolic process
GO:0097053	L-kynurenine catabolic process