InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Cyb5r3

Summary

InnateDB Protein

IDBP-167911.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Cyb5r3

Protein Name

cytochrome b5 reductase 3

Synonyms

0610016L08Rik; 2500002N19Rik; C85115; Dia-1; Dia1; WU:AL591952.1-001; WU:AL591952.1-002; WU:AL591952.1-003; WU:Cyb5r3;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000018186

InnateDB Gene

IDBG-167907 (Cyb5r3)

Protein Structure

UniProt Annotation

Function

Desaturation and elongation of fatty acids, cholesterol biosynthesis, drug metabolism, and, in erythrocyte, methemoglobin reduction. {ECO:0000250}.

Subcellular Localization

Isoform 1: Endoplasmic reticulum membrane {ECO:0000250}; Lipid-anchor {ECO:0000250}; Cytoplasmic side {ECO:0000250}. Mitochondrion outer membrane {ECO:0000250}; Lipid- anchor {ECO:0000250}; Cytoplasmic side {ECO:0000250}.Isoform 2: Cytoplasm, cytosol {ECO:0000250}. Note=Produces the soluble form found in erythrocytes. {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 13 experimentally validated interaction(s) in this database.
They are also associated with 8 interaction(s) predicted by orthology.

Experimentally validated
Total	13 [view]
Protein-Protein	12 [view]
Protein-DNA	0
Protein-RNA	1 [view]
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	8 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004128	cytochrome-b5 reductase activity, acting on NAD(P)H
GO:0005515	protein binding
GO:0016208	AMP binding
GO:0016491	oxidoreductase activity
GO:0043531	ADP binding
GO:0050660	flavin adenine dinucleotide binding
GO:0051287	NAD binding
GO:0071949	FAD binding

Biological Process

GO:0006695	cholesterol biosynthetic process
GO:0055114	oxidation-reduction process

Cellular Component

GO:0005739	mitochondrion
GO:0005741	mitochondrial outer membrane
GO:0005743	mitochondrial inner membrane
GO:0005783	endoplasmic reticulum
GO:0005789	endoplasmic reticulum membrane
GO:0005811	lipid particle
GO:0005829	cytosol
GO:0016020	membrane
GO:0070062	extracellular vesicular exosome

Protein Structure and Domains

PDB ID

MGI:94893

InterPro

IPR001433 Oxidoreductase FAD/NAD(P)-binding
IPR001709 Flavoprotein pyridine nucleotide cytochrome reductase
IPR001834 NADH:cytochrome b5 reductase (CBR)
IPR008333 Oxidoreductase, FAD-binding domain
IPR013121 Ferric reductase, NAD binding
IPR017938 Riboflavin synthase-like beta-barrel

PFAM

PF00175
PF00970
PF08030

PRINTS

PR00371
PR00406

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q9DCN2