InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Etfa

Summary

InnateDB Protein

IDBP-167941.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Etfa

Protein Name

electron transferring flavoprotein, alpha polypeptide

Synonyms

2010200I21Rik; D9Ertd394e;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000034866

InnateDB Gene

IDBG-167939 (Etfa)

Protein Structure

UniProt Annotation

Function

The electron transfer flavoprotein serves as a specific electron acceptor for several dehydrogenases, including five acyl- CoA dehydrogenases, glutaryl-CoA and sarcosine dehydrogenase. It transfers the electrons to the main mitochondrial respiratory chain via ETF-ubiquinone oxidoreductase (ETF dehydrogenase) (By similarity). {ECO:0000250}.

Subcellular Localization

Mitochondrion matrix {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 13 experimentally validated interaction(s) in this database.
They are also associated with 19 interaction(s) predicted by orthology.

Experimentally validated
Total	13 [view]
Protein-Protein	13 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	19 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0009055	electron carrier activity
GO:0016491	oxidoreductase activity
GO:0050660	flavin adenine dinucleotide binding

Biological Process

GO:0055114

oxidation-reduction process

Cellular Component

GO:0005739	mitochondrion
GO:0017133	mitochondrial electron transfer flavoprotein complex
GO:0070062	extracellular vesicular exosome

Protein Structure and Domains

PDB ID

MGI:106092

InterPro

IPR001308 Electron transfer flavoprotein, alpha subunit
IPR014730 Electron transfer flavoprotein, alpha/beta-subunit, N-terminal
IPR014731 Electron transfer flavoprotein, alpha subunit, C-terminal
IPR029035 DHS-like NAD/FAD-binding domain

PFAM

PF01012
PF00766

PRINTS

PIRSF

PIRSF000089

SMART

SM00893

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt