InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Calr3

Summary

InnateDB Protein

IDBP-168002.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Calr3

Protein Name

calreticulin 3

Synonyms

1700031L01Rik; 6330586I20Rik; Crt2; cspn;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000019876

InnateDB Gene

IDBG-168000 (Calr3)

Protein Structure

UniProt Annotation

Function

CALR3 capacity for calcium-binding may be absent or much lower than that of CALR (By similarity). During spermatogenesis, may act as a lectin-independent chaperone for specific client proteins such as ADAM3. Required for sperm fertility. {ECO:0000250, ECO:0000269PubMed:21131354}.

Subcellular Localization

Endoplasmic reticulum lumen {ECO:0000250}.

Disease Associations

Tissue Specificity

Testis specific, absent in mature sperm. {ECO:0000269PubMed:12384296, ECO:0000269PubMed:21131354}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.

Experimentally validated
Total	3 [view]
Protein-Protein	3 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005509	calcium ion binding
GO:0005515	protein binding
GO:0044183	protein binding involved in protein folding
GO:0051082	unfolded protein binding

Biological Process

GO:0006457	protein folding
GO:0007283	spermatogenesis
GO:0030154	cell differentiation

Cellular Component

GO:0005783	endoplasmic reticulum
GO:0005788	endoplasmic reticulum lumen

Protein Structure and Domains

PDB ID

MGI:1920566

InterPro

IPR001580 Calreticulin/calnexin
IPR008985 Concanavalin A-like lectin/glucanases superfamily
IPR009033 Calreticulin/calnexin, P domain
IPR009169 Calreticulin

PFAM

PF00262

PRINTS

PR00626

PIRSF

PIRSF002356

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt