InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: S100a6

Summary

InnateDB Protein

IDBP-168018.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

S100a6

Protein Name

S100 calcium binding protein A6 (calcyclin)

Synonyms

2A9; 5B10; Cacy; CALCYCLIN; PRA;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000001051

InnateDB Gene

IDBG-168016 (S100a6)

Protein Structure

UniProt Annotation

Function

May function as calcium sensor and modulator, contributing to cellular calcium signaling. May function by interacting with other proteins, such as TPR-containing proteins, and indirectly play a role in many physiological processes such as the reorganization of the actin cytoskeleton and in cell motility. Binds 2 calcium ions. Calcium binding is cooperative (By similarity). {ECO:0000250}.

Subcellular Localization

Nucleus envelope {ECO:0000250}. Cytoplasm {ECO:0000250}. Cell membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Cytoplasmic side {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 9 experimentally validated interaction(s) in this database.
They are also associated with 21 interaction(s) predicted by orthology.

Experimentally validated
Total	9 [view]
Protein-Protein	9 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	21 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005509	calcium ion binding
GO:0005515	protein binding
GO:0005523	tropomyosin binding
GO:0008270	zinc ion binding
GO:0015075	ion transmembrane transporter activity
GO:0042803	protein homodimerization activity
GO:0044548	S100 protein binding
GO:0048306	calcium-dependent protein binding

Biological Process

GO:0034220

ion transmembrane transport

Cellular Component

GO:0001726	ruffle
GO:0005634	nucleus
GO:0005635	nuclear envelope
GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0031234	extrinsic component of cytoplasmic side of plasma membrane
GO:0048471	perinuclear region of cytoplasm
GO:0070062	extracellular vesicular exosome