InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: ZNF703

Summary

InnateDB Protein

IDBP-16806.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ZNF703

Protein Name

zinc finger protein 703

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000332325

InnateDB Gene

IDBG-16804 (ZNF703)

Protein Structure

UniProt Annotation

Function

Transcriptional corepressor which does not bind directly to DNA and may regulate transcription through recruitment of histone deacetylases to gene promoters. Regulates cell adhesion, migration and proliferation. May be required for segmental gene expression during hindbrain development. {ECO:0000269PubMed:21328542, ECO:0000269PubMed:21337521}.

Subcellular Localization

Nucleus {ECO:0000269PubMed:21328542, ECO:0000269PubMed:21337521}. Cytoplasm {ECO:0000250}.

Disease Associations

Note=Luminal B breast cancers are the clinically more aggressive estrogen receptor-positive tumors. Amplification of a distal 8p12 locus occurs in around one third of the cases and ZNF703 is the single gene within the minimal amplicon. Amplification of the gene correlates with its protein expression in tumor cells. ZNF703 is a classical breast cancer oncogene since it is able to transform non-malignant cells and increase cellular proliferation.

Tissue Specificity

Expressed in mammary epithelium. {ECO:0000269PubMed:21317240}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.

Experimentally validated
Total	4 [view]
Protein-Protein	4 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003676	nucleic acid binding
GO:0005515	protein binding
GO:0046872	metal ion binding
GO:0070491	repressing transcription factor binding

Biological Process

GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0008284	positive regulation of cell proliferation
GO:0010718	positive regulation of epithelial to mesenchymal transition
GO:0017015	regulation of transforming growth factor beta receptor signaling pathway
GO:0030335	positive regulation of cell migration
GO:0033601	positive regulation of mammary gland epithelial cell proliferation
GO:0034111	negative regulation of homotypic cell-cell adhesion
GO:0034333	adherens junction assembly
GO:0045892	negative regulation of transcription, DNA-templated
GO:0051726	regulation of cell cycle
GO:0060644	mammary gland epithelial cell differentiation
GO:0060828	regulation of canonical Wnt signaling pathway
GO:0071392	cellular response to estradiol stimulus