InnateDB Protein
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IDBP-168159.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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Ell2
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Protein Name
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elongation factor RNA polymerase II 2
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Synonyms
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Species
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Mus musculus
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Ensembl Protein
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ENSMUSP00000001583
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InnateDB Gene
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IDBG-168157 (Ell2)
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Protein Structure
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Function |
Elongation factor component of the super elongation complex (SEC), a complex required to increase the catalytic rate of RNA polymerase II transcription by suppressing transient pausing by the polymerase at multiple sites along the DNA. Component of the little elongation complex (LEC), a complex required to regulate small nuclear RNA (snRNA) gene transcription by RNA polymerase II and III (By similarity). Plays a role in immunoglobulin secretion in plasma cells: directs efficient alternative mRNA processing, influencing both proximal poly(A) site choice and exon skipping, as well as immunoglobulin heavy chain (IgH) alternative processing. Probably acts by regulating histone modifications accompanying transition from membrane- specific to secretory IgH mRNA expression. {ECO:0000250, ECO:0000269PubMed:19749764, ECO:0000269PubMed:21832080}.
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Subcellular Localization |
Nucleus {ECO:0000250}.
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Disease Associations |
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Tissue Specificity |
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 21 interaction(s) predicted by orthology.
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Predicted by orthology |
Total |
21 [view]
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Molecular Function |
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Biological Process |
GO:0006355
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regulation of transcription, DNA-templated
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GO:0006368
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transcription elongation from RNA polymerase II promoter
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Cellular Component |
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PDB ID |
MGI:2183438
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InterPro |
IPR010844
Occludin/RNA polymerase II elongation factor, ELL domain
IPR019464
RNA polymerase II elongation factor ELL
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PFAM |
PF07303
PF10390
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q3UKU1
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PhosphoSite |
PhosphoSite-Q3UKU1
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TrEMBL |
Q3US23
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UniProt Splice Variant |
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Entrez Gene |
192657
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UniGene |
Mm.488343
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RefSeq |
NP_620403
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MGI ID |
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MGI Symbol |
Ell2
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OMIM |
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CCDS |
CCDS36734
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HPRD |
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IMGT |
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EMBL |
AK140906
AK145868
CT025556
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GenPept |
BAE24514
BAE26710
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