InnateDB Protein
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IDBP-168162.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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Hmgn5
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Protein Name
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high-mobility group nucleosome binding domain 5
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Synonyms
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GARP45; NBP-45; Nsbp1;
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Species
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Mus musculus
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Ensembl Protein
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ENSMUSP00000033597
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InnateDB Gene
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IDBG-168160 (Hmgn5)
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Protein Structure
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Function |
Preferentially binds to euchromatin and modulates cellular transcription by counteracting linker histone-mediated chromatin compaction. {ECO:0000269PubMed:10692437, ECO:0000269PubMed:19748358}.
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Subcellular Localization |
Nucleus {ECO:0000269PubMed:10692437, ECO:0000269PubMed:19748358}. Note=Associates with nucleosomes in euchromatin and is largely excluded from constitutive heterochromatin.
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Disease Associations |
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Tissue Specificity |
Expressed in liver, spleen, lung, heart, kidney, muscle and brain (at protein level). Widely expressed with highest levels in submaxillary gland, thymus, kidney and liver and lowest levels in brain, lung, pancreas and eye. {ECO:0000269PubMed:10692437, ECO:0000269PubMed:19748358}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Experimentally validated |
Total |
3
[view]
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Protein-Protein |
3
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
3 [view]
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
MGI:1355295
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InterPro |
IPR000079
High mobility group nucleosome-binding domain-containing family
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PFAM |
PF01101
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PRINTS |
PR00925
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PIRSF |
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SMART |
SM00527
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TIGRFAMs |
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Modification |
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SwissProt |
Q9JL35
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PhosphoSite |
PhosphoSite-Q9JL35
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
50887
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UniGene |
Mm.298443
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RefSeq |
NP_057919
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MGI ID |
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MGI Symbol |
Hmgn5
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OMIM |
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CCDS |
CCDS41101
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HPRD |
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IMGT |
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EMBL |
AB018374
AF213454
AK013748
AK131996
AL954348
BC021626
BC083087
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GenPept |
AAF30179
AAH21626
AAH83087
BAA33783
BAB28982
BAE20926
CAM15237
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