Version 5.4
Mus musculus Protein: Hmgn5
Summary
InnateDB Protein IDBP-168162.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Hmgn5
Protein Name high-mobility group nucleosome binding domain 5
Synonyms GARP45; NBP-45; Nsbp1;
Species Mus musculus
Ensembl Protein ENSMUSP00000033597
InnateDB Gene IDBG-168160 (Hmgn5)
Protein Structure
UniProt Annotation
Function Preferentially binds to euchromatin and modulates cellular transcription by counteracting linker histone-mediated chromatin compaction. {ECO:0000269PubMed:10692437, ECO:0000269PubMed:19748358}.
Subcellular Localization Nucleus {ECO:0000269PubMed:10692437, ECO:0000269PubMed:19748358}. Note=Associates with nucleosomes in euchromatin and is largely excluded from constitutive heterochromatin.
Disease Associations
Tissue Specificity Expressed in liver, spleen, lung, heart, kidney, muscle and brain (at protein level). Widely expressed with highest levels in submaxillary gland, thymus, kidney and liver and lowest levels in brain, lung, pancreas and eye. {ECO:0000269PubMed:10692437, ECO:0000269PubMed:19748358}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Experimentally validated
Total 3 [view]
Protein-Protein 3 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 3 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003682 chromatin binding
GO:0031492 nucleosomal DNA binding
GO:0044822 poly(A) RNA binding
Biological Process
GO:0006351 transcription, DNA-templated
GO:0006357 regulation of transcription from RNA polymerase II promoter
GO:0016568 chromatin modification
Cellular Component
GO:0000785 chromatin
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005730 nucleolus
GO:0043231 intracellular membrane-bounded organelle
Protein Structure and Domains
PDB ID MGI:1355295
InterPro IPR000079 High mobility group nucleosome-binding domain-containing family
PFAM PF01101
PRINTS PR00925
PIRSF
SMART SM00527
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9JL35
PhosphoSite PhosphoSite-Q9JL35
TrEMBL
UniProt Splice Variant
Entrez Gene 50887
UniGene Mm.298443
RefSeq NP_057919
MGI ID
MGI Symbol Hmgn5
OMIM
CCDS CCDS41101
HPRD
IMGT
EMBL AB018374 AF213454 AK013748 AK131996 AL954348 BC021626 BC083087
GenPept AAF30179 AAH21626 AAH83087 BAA33783 BAB28982 BAE20926 CAM15237

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca