InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Pglyrp3

Summary

InnateDB Protein

IDBP-168191.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Pglyrp3

Protein Name

peptidoglycan recognition protein 3

Synonyms

Species

Mus musculus

Ensembl Protein

ENSMUSP00000035737

InnateDB Gene

IDBG-168189 (Pglyrp3)

Protein Structure

UniProt Annotation

Function

Pattern receptor that binds to murein peptidoglycans (PGN) of Gram-positive bacteria. Has bactericidal activity towards Gram-positive bacteria. May kill Gram-positive bacteria by interfering with peptidoglycan biosynthesis. Binds also to Gram- negative bacteria, and has bacteriostatic activity towards Gram- negative bacteria. Plays a role in innate immunity (By similarity). {ECO:0000250}.

Subcellular Localization

Secreted {ECO:0000250}.

Disease Associations

Tissue Specificity

Detected in lung, spleen and stomach, and at low levels in eye, heart, thymus and testis. {ECO:0000269PubMed:15177568}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0008270	zinc ion binding
GO:0008745	N-acetylmuramoyl-L-alanine amidase activity
GO:0016019	peptidoglycan receptor activity
GO:0042834	peptidoglycan binding

Biological Process

GO:0002221	pattern recognition receptor signaling pathway
GO:0009253	peptidoglycan catabolic process
GO:0016045	detection of bacterium
GO:0032689	negative regulation of interferon-gamma production
GO:0032827	negative regulation of natural killer cell differentiation involved in immune response
GO:0044117	growth of symbiont in host
GO:0045087	innate immune response (InnateDB)
GO:0050830	defense response to Gram-positive bacterium