Version 5.4
Mus musculus Protein: Serpina3k
Summary
InnateDB Protein IDBP-168194.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Serpina3k
Protein Name serine (or cysteine) peptidase inhibitor, clade A, member 3K
Synonyms 1300001I07Rik; contrapsin; D12Rp54; MMCM2; MMSpi2; RP54; Spi-2; Spi2;
Species Mus musculus
Ensembl Protein ENSMUSP00000042095
InnateDB Gene IDBG-168192 (Serpina3k)
Protein Structure
UniProt Annotation
Function Contrapsin inhibits trypsin-like proteases. {ECO:0000269PubMed:6214866, ECO:0000269PubMed:6224776}.
Subcellular Localization Secreted.
Disease Associations
Tissue Specificity Expressed in liver and secreted in plasma. {ECO:0000269PubMed:15638460, ECO:0000269PubMed:2049065, ECO:0000269PubMed:6214866, ECO:0000269PubMed:6224776}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 10 experimentally validated interaction(s) in this database.
Experimentally validated
Total 10 [view]
Protein-Protein 10 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004867 serine-type endopeptidase inhibitor activity
GO:0005515 protein binding
Biological Process
GO:0010951 negative regulation of endopeptidase activity
GO:0030162 regulation of proteolysis
GO:0034097 response to cytokine
GO:0043434 response to peptide hormone
Cellular Component
GO:0005576 extracellular region
GO:0005615 extracellular space
Protein Structure and Domains
PDB ID MGI:98377
InterPro IPR023796 Serpin domain
PFAM PF00079
PRINTS
PIRSF
SMART SM00093
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt P07759
PhosphoSite PhosphoSite-P07759
TrEMBL
UniProt Splice Variant
Entrez Gene 20714
UniGene Mm.489823
RefSeq NP_035588
MGI ID
MGI Symbol Serpina3k
OMIM
CCDS CCDS36537
HPRD
IMGT
EMBL AK149436 BC011217 BC016407 BC019802 D00725 X00946 X55147 X56786
GenPept AAH11217 AAH16407 AAH19802 BAA00627 BAE28874 CAA25458 CAA38948 CAA40106

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca