InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Nkx2-3

Summary

InnateDB Protein

IDBP-168199.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Nkx2-3

Protein Name

NK2 transcription factor related, locus 3 (Drosophila)

Synonyms

Nkx-2.3; Nkx2.3; tinman;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000050933

InnateDB Gene

IDBG-168197 (Nkx2-3)

Protein Structure

UniProt Annotation

Function

Transcriptional regulator essential for normal development and functions of the small intestine and spleen. Activates directly MADCAM1 expression. Required for homing of lymphocytes in spleen and mucosa-associated lymphoid tissue. May have a role during pharyngeal organogenesis. {ECO:0000269PubMed:10790368}.

Subcellular Localization

Nucleus {ECO:0000305}.

Disease Associations

Tissue Specificity

Expressed in spleen and intestine. Also expressed in salivary gland and tongue. {ECO:0000269PubMed:12141427}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	2 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0043565	sequence-specific DNA binding

Biological Process

GO:0001776	leukocyte homeostasis
GO:0002317	plasma cell differentiation
GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0006641	triglyceride metabolic process
GO:0006955	immune response
GO:0009791	post-embryonic development
GO:0022612	gland morphogenesis
GO:0030183	B cell differentiation
GO:0030225	macrophage differentiation
GO:0042127	regulation of cell proliferation
GO:0042475	odontogenesis of dentin-containing tooth
GO:0043367	CD4-positive, alpha-beta T cell differentiation
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0048535	lymph node development
GO:0048536	spleen development
GO:0048537	mucosal-associated lymphoid tissue development
GO:0048541	Peyer's patch development
GO:0048565	digestive tract development
GO:0048621	post-embryonic digestive tract morphogenesis
GO:0050900	leukocyte migration