Version 5.4
Mus musculus Protein: Glrx
Summary
InnateDB Protein IDBP-168211.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Glrx
Protein Name glutaredoxin
Synonyms C86710; D13Wsu156e; Glrx1; Grx1; TTase;
Species Mus musculus
Ensembl Protein ENSMUSP00000022082
InnateDB Gene IDBG-168209 (Glrx)
Protein Structure
UniProt Annotation
Function Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins.
Subcellular Localization Cytoplasm.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 8 interaction(s) predicted by orthology.
Experimentally validated
Total 1 [view]
Protein-Protein 0
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 8 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0009055 electron carrier activity
GO:0015035 protein disulfide oxidoreductase activity
GO:0019153 protein-disulfide reductase (glutathione) activity
GO:0047485 protein N-terminus binding
Biological Process
GO:0045087 innate immune response (InnateDB)
GO:0045454 cell redox homeostasis
GO:0055114 oxidation-reduction process
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0070062 extracellular vesicular exosome
Protein Structure and Domains
PDB ID MGI:2135625
InterPro IPR002109 Glutaredoxin
IPR011899 Glutaredoxin, eukaryotic/virial
IPR012336 Thioredoxin-like fold
IPR014025 Glutaredoxin subgroup
PFAM PF00462
PF13098
PF13192
PF13462
PF13905
PRINTS PR00160
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9QUH0
PhosphoSite PhosphoSite-Q9QUH0
TrEMBL Q3U6L3
UniProt Splice Variant
Entrez Gene 93692
UniGene Mm.421043
RefSeq NP_444338
MGI ID
MGI Symbol Glrx
OMIM
CCDS CCDS26651
HPRD
IMGT
EMBL AB013137 AF109314 AF276917 AK153086 BC012642 CH466563
GenPept AAF04780 AAF86464 AAH12642 BAA86926 BAE31711 EDL37108 EDL37109

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca