Version 5.4
Mus musculus Protein: Tapbp
Summary
InnateDB Protein IDBP-168252.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Tapbp
Protein Name TAP binding protein
Synonyms D17Wsu91e; TPN;
Species Mus musculus
Ensembl Protein ENSMUSP00000025161
InnateDB Gene IDBG-168250 (Tapbp)
Protein Structure
UniProt Annotation
Function Involved in the association of MHC class I with transporter associated with antigen processing (TAP) and in the assembly of MHC class I with peptide (peptide loading).
Subcellular Localization Endoplasmic reticulum membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 11 experimentally validated interaction(s) in this database.
They are also associated with 13 interaction(s) predicted by orthology.
Experimentally validated
Total 11 [view]
Protein-Protein 8 [view]
Protein-DNA 3 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 13 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0002397 MHC class I protein complex assembly
GO:0002479 antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent
GO:0006952 defense response
GO:0019885 antigen processing and presentation of endogenous peptide antigen via MHC class I
GO:0050823 peptide antigen stabilization
Cellular Component
GO:0005887 integral component of plasma membrane
GO:0030670 phagocytic vesicle membrane
GO:0042824 MHC class I peptide loading complex
Protein Structure and Domains
PDB ID MGI:1201689
InterPro IPR003597 Immunoglobulin C1-set
IPR007110 Immunoglobulin-like domain
IPR008056 Tapasin
PFAM PF07654
PRINTS PR01669
PIRSF
SMART SM00407
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9R233
PhosphoSite PhosphoSite-Q9R233
TrEMBL Q8C6N4
UniProt Splice Variant
Entrez Gene 21356
UniGene Mm.488171
RefSeq NP_033344
MGI ID
MGI Symbol Tapbp
OMIM
CCDS CCDS37572
HPRD
IMGT
EMBL AF043943 AF100956 AF106278 AF110520 AJ316612 AJ316613 AK054174 AK151134 AK151807 AK151878 AK152019 AK152726 AK170528 AY734476 AY734477 CH466660 CR974462
GenPept AAC61676 AAC69893 AAC97973 AAD17964 AAU50684 AAU50685 BAC35681 BAE30142 BAE30706 BAE30764 BAE30881 BAE31448 BAE41860 CAC69993 CAC70721 EDL10226

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca